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Dual-agonist approach

Tirzepatide is a dual GIP and GLP-1 receptor agonist that targets multiple pathways involved in weight, metabolism, and blood sugar regulation.

Medical provider oversight

Your treatment is guided by a licensed clinician who reviews your health history, lab work, and goals to ensure it’s appropriate and safe for you.

Ongoing follow-up

We monitor your progress, adjust your plan as needed, and provide continued support to help you achieve lasting results.

Two receptors, not one

Semaglutide activates the GLP-1 receptor. Tirzepatide activates GLP-1 and GIP — a second incretin receptor involved in insulin sensitivity and fat metabolism.

The practical effect is that you feel full sooner, stay full longer, and your body handles glucose more efficiently between meals. Most patients describe it as the constant background negotiation with food going quiet.

It is not a stimulant and not a fat burner. It changes appetite signalling, which is why it works only while you take it and why the plan around it matters as much as the molecule.

DUAL-HORMONE POWER

Tirzepatide targets GLP-1 and GLP-2 receptors for amplified fat-burning.

WHAT CLINICAL RESEARCH SHOWS

Adults experienced reductions of 15.0%, 19.5%, and 20.9%

ONCE-A-WEEK DOSING

Easy self-injection from home. No daily pills or drops.

REDUCED CRAVINGS

Say goodbye to food noise and mindless snacking.
WHAT TO EXPECT

Honestly, Over Time

WEEK 1–2

Something feels different

Portions get harder to finish. Some nausea, usually 24-48 hours after your shot.
WEEK 4–8

The scale moves

Measurable change begins.
Constipation is common – fiber and water matter more than people expect.
MONTH 3–6

The steady stretch

The most consistent loss happens here. Resistance training protects lean mass.
MONTH 9–18

Plateau and maintenance

Loss slows as your body adapts. Your provider discusses maintenance rather than stopping cold.
PROTOCOL

How Treatment Usually Runs

A typical schedule. Yours is set by your clinician and adjusted as you go.
PHASEWEEKSTYPICALPURPOSE
Start1-42.5 mg weeklyTolerance only . This dose is not expected to drive weight loss
First step up5-85 mg weeklyThe first therapeutic dose . Most people notice appetite change here
Build9-167.5-10 mg weekly Increases continue only if side effects stay manageable
Maintenance17+10-15 mg weekly Held at the lowest dose that keeps progress steady
EVIDENCE

What the
Research Shows

Tirzepatide is a dual GIP and GLP-1 receptor agonist used in FDA-approved medications for chronic weight management and type 2 diabetes.
Clinical studies on FDA-approved tirzepatide have shown meaningful average body weight reduction in adults with obesity or overweight.
Research continues to evaluate tirzepatide’s role in weight, metabolic markers, glucose regulation, and long-term cardiometabolic care.
At California Trim Clinic, treatment options are reviewed by a licensed provider to determine eligibility, dosing, and appropriate medical monitoring.
Compounded tirzepatide is prepared for individual patient needs when clinically appropriate, but compounded medications are not FDA-approved.
FAQ

Your Peptide Therapy
Questions

In the SURMOUNT-1 trial of Zepbound® (tirzepatide), adults with obesity lost an average of about 20% of total body weight at the highest dose over 72 weeks. Individual results vary widely and depend on dose, adherence, diet, activity and medical history.

In comparable trials, Tirzepatide produced greater average weight reduction. It is not automatically the better choice for you — tolerance, cost, availability and medical history all factor into what your provider recommends.

Most patients notice reduced appetite within one to two weeks of the first therapeutic dose. Measurable weight change typically appears between week four and week eight and continues as the dose titrates upward.

Nausea, constipation, diarrhoea, fatigue and injection-site reactions. They are most pronounced in the days following a dose increase and usually ease as your body adjusts. Severe persistent abdominal pain requires immediate medical attention.

Not necessarily, but appetite typically returns to baseline after stopping and weight regain is common without a maintenance plan. Your provider will discuss tapering, maintenance dosing and lifestyle strategy before you stop.

Every prescription is written by a licensed provider after a live visit and dispensed by a licensed pharmacy. Your provider prescribes only when it is clinically appropriate for you, orders bloodwork when your treatment calls for it, and reviews you on an ongoing basis.

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